Effect of kuvan on relaxation of diet in phenylketonuria
Not Applicable
- Conditions
- mild phenylketonuria.Other hyperphenylalaninaemias
- Registration Number
- IRCT2016100230082N1
- Lead Sponsor
- Mashhad University of Medical Sciences, Vice Chancellor for Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
patients with controlled PKU; age range of 1-10 years; lack of underlying disorders (e.g. malnutrition, hepatic and renal diseases).
Exclusion criteria: BH4 deficiency; Phe levels less than 600 micromoles/liter or more than 1200 micromoles/liter; presence of fever or acute illness; intolerance to BH4 therapy.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum levels of phenylalanine. Timepoint: In first phases, after three days of free diet, then 24 and 48 houres after prescription of BH4. In second phase, measured weekly. Method of measurement: HPLC.
- Secondary Outcome Measures
Name Time Method