Comparison of efficacy and safety of azathioprine and methotrexate in patients of hand eczema.
Phase 4
- Conditions
- Health Condition 1: L308- Other specified dermatitis
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients diagnosed as moderate to severe hand eczema (HECSI score >12).
Age >18 years.
Exclusion Criteria
1.Patients with hepatic/ renal disease/pulmonary fibrosis.
2.Severe anaemia, leucopenia or thrombocytopenia.
3.Active infectious disease or immune system deficiency including AIDS.
4.Pregnant or lactating women.
5.Significant abnormalities in liver function (serum bilirubin, AST, ALT, and ALP > 1.5 times the upper limit of normal), viral hepatitis or cirrhosis.
6.H/o excessive alcohol consumption.
7.H/o intolerance/hypersensitivity to azathioprine and/or methotrexate.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the clinical and functional outcome in each group, as assessed by HECSI and DLQI. <br/ ><br>To compare the safety and tolerability of each drug by regular evaluation of clinical and biochemical parameters.Timepoint: week 2, 4, 8 and 12 <br/ ><br>
- Secondary Outcome Measures
Name Time Method ã??Evaluate the clinicodemographic factors predicting response in each group. <br/ ><br>To study the MOAHLFA index for demographic characteristics of patients.Timepoint: week 2,4,8 and 12