Very Advanced Maternal Aged Pregnants and Early Adolescent Pregnant Women

Completed

• Conditions: Advanced Maternal Age Pregnancy; Early Pregnancy

• Registration Number: NCT05484869
• Lead Sponsor: Siirt University

Brief Summary

Maternal age is an important factor affecting the pregnancy process and its results. Adverse obstetric outcomes such as preterm birth, stillbirth, and infant mortality are more common in women older than 35 years and younger than 20 years compared to women aged 20-29. Adolescent pregnancies have been associated with an increased risk of adverse pregnancy outcomes such as preterm birth, low birth weight, perinatal death, and maternal mortality.

Advanced maternal age pregnancies were associated with higher rates of maternal hypertension and diabetes, and progressively worsening perinatal outcomes such as stillbirth, preterm birth, and low birth weight.

Although the investigators' region has high birth rates, as far as they have observed, the rates of early and advanced maternal age are also quite high. the investigators' aim in this study is to determine the absolute effects of early and advanced maternal age on pregnancy and to investigate the pregnancy outcomes of these mothers.

Detailed Description

The investigators' aim in this study is to determine the absolute effects of early and advanced maternal age on pregnancy and to investigate the pregnancy outcomes of these mothers. For this purpose, the information of 90 pregnant women followed in Siirt Training and Research Hospital between 2017-2021 will be accessed through the hospital's data system. Maternal age, pregnancy history, Assisted reproductive technologies history, laboratory findings, screening test results, mode of delivery, baby birth information, pregnancy complications and complications during delivery will be recorded. In the light of the information gathered, the rates of negative effects of gestational age on pregnancy will be calculated.

Study Timeline

• Study Start: 2017-01-01
• Primary Completion: 2021-12-30
• Study Completion: 2021-12-30
• Study First Submitted: 2022-07-22
• Study First Submitted QC: 2022-07-30
• Status Verified: 2022-08
• Study First Posted: 2022-08-02
• Last Update Submitted: 2022-08-27
• Last Update Posted: 2022-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 297

Inclusion Criteria

• Pregnants under the age of 16 and younger
• pregnants over the age of 45 and older

Exclusion Criteria

• history of chronic hypertension
• history of pre gestational diabetes
• history of chronic diseases
• excessive consumption of alcohol
• smoking pregnants
• kidney disorders

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Delivery type in pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	The % of delivery type (vaginal delivery/ cesarean section) will be compared between the three groups
Abortion ratio of pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of abortion will be compared between the three groups
Intrauterine growth retardation ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of intrauterine growth retardation (IUGR) will be compared between the three groups
Postpartum hemorrhage ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of postpartum hemorrhage will be compared between the three groups
Placenta previa ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of placenta previa will be compared between the three groups
Mean fetal weight of pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1month	The fetal weight (in grams) will be compared between the three groups
Ratio of male, female gender in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	% of male, female gender will be compared between the three groups
Mean APGAR scores in the 1st minute in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	APGAR scores in the 1st minute (by numbers) will be compared between the three groups
Mean APGAR scores in the 5th minute in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	APGAR scores in the 5th minute (by numbers) will be compared between the three groups
Neonatal death ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of neonatal death will be compared between the three groups
Premature rupture of membranes in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of premature rupture of membranes (PROM) will be compared between the three groups
Preterm labor ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of preterm labor will be compared between the three groups
Ablatio placentae ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of ablatio placentae will be compared between the three groups
Fetal Distress ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of fetal distress will be compared between the three groups
Intrauterine death ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of intrauterine death will be compared between the three groups
Gestational diabetes ratio in pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of gestational diabetes mellitus (GDM) will be compared between the three groups
Preeclampsia ratio in pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of preeclampsia will be compared between the three groups
Surmaturation ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of surmaturation will be compared between the three groups
Polyhydramnios ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of polyhydramnios will be compared between the three groups
Oligohydramnios ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of oligohydramnios will be compared between the three groups
Presentation anomaly ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of presentation anomaly will be compared between the three groups
Multiple pregnancy ratio in pregnancies of pregnant women under the age of 16 ( group 1), over the age of 45 (group 2) and between the age of 25-35 (group 3).	1 month	Rate and % of multiple pregnancy will be compared between the three groups