Comparative Evaluation of Levels of Salivary Visfatin and Aspartate Aminotransferase in Stage-II and Stage-III Periodontitis treated by Phase I Periodontal Therapy - A Prospective Clinical Study.
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Levels of Salivary Visfatin and
研究概览
简要总结
Periodontitis is one of the most prevalent oral diseases in the world. Approximately 5–20% of adults worldwide suffer from severe periodontitis which may lead to tooth loss. Biomarkers found in saliva can be evaluated to check for disease activity. Visfatin is a pre-B cell colony enhancing factor, a newly discovered adipokine released from adipose tissue, macrophages, and leukocytes. Aspartate aminotransferase (AST) is an enzyme that can be found in cells all over the body and there is a direct relation between AST level and quantity of tissue impairment. This biomarker will provides a safe, and non-invasive approach for periodontal disease detection, and possesses a high potential to revolutionize the next generation of diagnostics. Thus , the aim of this study was to evaluate the role of visfatin and Aspartate aminotransferase as best reliable diagnostic and prognostic biomarkers in oral diseases like periodontitis .
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Male and female patients of age groups 18 to 70 years.
- •Minimum 20 teeth should be present.
- •Patient diagnosed as Stage-II or Stage-III periodontitis.
- •Systemically healthy patients.
- •Patients ready to comply fully and willing to give consent form the final evaluation.
- •Patients having ability to maintain optimum oral hygiene.
排除标准
- •Patients with systemic diseases.
- •Smoking and alcoholism
- •Teeth no less than
- •Patients on antibiotics and anti-inflammatory drugs since 6 months.
- •Pregnant or lactating females.
- •Patients undergoing orthodontic treatment.
- •Those who have undergone periodontal surgical treatment with in the last 6 months
- •Patient with obesity (BMI- more or equal to 30).
结局指标
主要结局
Levels of Salivary Visfatin and
时间窗: 1st measurement at baseline and 2nd measurement at 4 weeks after Phase - I Periodontal therapy
Aspartate Aminotransferase
时间窗: 1st measurement at baseline and 2nd measurement at 4 weeks after Phase - I Periodontal therapy
次要结局
- 1) Probing pocket depth(2) Clinical attachment level)