A Comparative study to evaluate the effectiveness of sonophoresis as an adjunct to non-surgical periodontal therapy.
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Periodontal probing depth in mm, MMP-8 levels in saliva using ELISA, bacterial colony forming units (CFU)
研究概览
简要总结
Periodontitis is a chronic inflammatory disease of multi factorial origin. 50 to 90% of adult population is affected by it, if untreated results in tooth loss. Non surgical periodontal therapy which involves scaling and root planing is considered as gold standard for the management of periodontal diseases. In the past many treatment modalities have been tried as an adjunct to non surgical periodontitis.
Sonophoresis is the use of therapeutic ultra sound in trans dermal drug delivery. It is commonly used in physiotherapy for the management of chronic inflammatory conditions. However, its application in dentistry is limited to the management of tempero mandibular joint disorders. This study aims to asses the role of sonophoresis as an adjunct to non surgical periodontal therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Chronic periodontitis (AAP 1999 classification) Probing depth of 5mm or more in more than 30% sites Systemically healthy No antibiotic useage in the last 6 months Did not undergo periodontal therapy in the last 6 months Non-pregnant, not lactating women.
排除标准
- •Patients with systemic diseases Patients allergic to metronidazole.
结局指标
主要结局
Periodontal probing depth in mm, MMP-8 levels in saliva using ELISA, bacterial colony forming units (CFU)
时间窗: baseline, 1 month post treatment
次要结局
- Clinical attachment level(Baseline, 1 month post treatment)
- Plaque index(Baseline and 1 month post treatment)
- Bleeding index(Baseline, 1 month post treatment)