ECLIPSE Study 9: Building resilience and recovery through enhancing cognition and quality

Not Applicable

Completed

• Conditions: on-affective psychosis; Mental and Behavioural Disorders; Schizophrenia, schizotypal and delusional disorders

• Registration Number: ISRCTN14678860
• Lead Sponsor: King's College London

Brief Summary

2018 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/29544551 protocol 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/36869733/ (added 06/03/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-06-06
• Study Completion: 2021-03-31
• Last Update Posted: 20 March 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 377

Inclusion Criteria

Current participant inclusion criteria as of 03/04/2019:
1. Attending an Early Intervention Service or any individual within 5 years of their first episode of psychosis. At least three months from the onset of the first episode of psychosis.
2. Aged between 16 and 45;
3. Research diagnosis of non-affective psychosis, i.e. schizophrenia, schizo-affective or schizophreniform disorder;
4. Ability to give informed consent.

Previous participant inclusion criteria (as of 15/01/2018)
1. Attending an Early Intervention Service for at least three months
2. Aged between 16 and 45
3. Research diagnosis of non-­affective psychosis, i.e. schizophrenia, schizo­affective or schizophreniform disorder
4. Ability to give informed consent

Previous participant inclusion criteria
1. Attending an Early Intervention Service for at least six months
2. Aged between 16 and 35
3. Research diagnosis of non-­affective psychosis, i.e. schizophrenia, schizo­affective or schizophreniform disorder
4. Ability to give informed consent

Exclusion Criteria

Current participant exclusion criteria as of 03/04/2019:
1. Inability to communicate in English sufficiently to participate in cognitive testing;
2. Underlying organic/neurological condition affecting cognition (e.g. traumatic brain injury, seizure disorder);
3. Co-morbid diagnosis of learning disability.
4. A definitive diagnosis of bipolar disorder

Previous participant exclusion criteria:
1. Inability to communicate in English sufficiently to participate in cognitive testing
2. Underlying organic/neurological condition affecting cognition(e.g. traumatic brain injury, seizure disorder)
3. Co­-morbid diagnosis of learning disability

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Achievement of goals is measured using the Goal Attainment Scale at baseline, post-CRT and at 6 months follow up

Secondary Outcome Measures

Name	Time	Method
<br> 1. Total number of hours of structured activity per week is measured using The Time Use Survey at baseline, post-CRT and at 6 months follow up<br> 2. Costs of health and social care use measured using The Client Service Receipt Inventory at baseline, post-CRT and at 6 months follow up<br> 3. Quality-adjusted life years (QALYs) measured using the EQ-5D at baseline, post-CRT and at 6 months follow up<br> 4. Self-esteem measured using the Rosenberg Self Esteem Scale at baseline, post-CRT and at 6 months follow up<br>