A randomized controlled trial of propofol versus placebo for the Emergency Department treatment of acute migraine in adults.
- Conditions
- Acute migraine.Neurological - Other neurological disorders
- Registration Number
- ACTRN12615000910505
- Lead Sponsor
- Dandenong Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Acute migraine, 18 to 65 years of age, patient reported pain on arrival of severity of 4 or more on the 1 to 10 numerical rating scale.
Any doubt about diagnosis of migraine for any reason, any associated head injury, any known intracranial pathology, systolic blood pressure less than100 mmHg, use of defined drugs in previous 4 hours (opioids, ergotamine, triptans, neuroleptics or antemetics other than ondansetron), known allergy to propofol, intralipid, egg or soy products. Migraine WITH aura comprising of neurological symptoms, aura being defined as: at least 2 of these, fully reversible aura symptoms: visual symptoms (flickering lights/spots/lines/visual loss) or Sensory symptoms (pins/needles/numbness), or Dysphasic speech disturbance; And at least 2 of these: Homonymous visual and/or unilateral sensory symptoms or at least one aura symptom developing over > 5 min, or Aura symptom(s) lasting between 5 and 60 minutes
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method % with headache resolution (pain score 0 on the Numerical Rating Scale) by one hour from initial treatment.[One hour from intial treatment.]
- Secondary Outcome Measures
Name Time Method