Impact of Limb Remote Ischemic Preconditioning on Mortality, Hospitalization Costs and Quality of Life During Elective Abdominal Aortic Aneurysm Repair: a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 360
- 主要终点
- all cause mortality
研究概览
简要总结
To investigate the influence of limb remote ischemic preconditioning (LRIP) on mortality, hospitalization costs and quality of life in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.
详细描述
Remote ischaemic preconditioning may confer the cytoprotection in critical organs. The investigators have revealed that limb remote ischemic preconditioning (RIPC) would reduce intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.Few groups have investigated the long term influence of limb remote ischemic preconditioning.Therefore, the investigators evaluated the impact of limb remote ischemic preconditioning on mortality, hospitalization costs and quality of life during elective abdominal aortic aneurysm repair in a prospective, randomized, controlled, single blind setting.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of abdominal aortic aneurysm
- •Must be received open abdominal aortic aneurysm repair
排除标准
- •age >80 years old
- •Acute coronary syndrome or myocardial infraction within 3 months
- •Chronic obstructive pulmonary emphysema
- •angina pain within 48 hours of repair procedure
- •ejection fraction less than 40%
- •poor pulmonary function (PaO2 <60mmHg)
结局指标
主要结局
all cause mortality
时间窗: one year
次要结局
- hospitalization costs(30 days after operation)
研究者
Cai Li
MD, PhD
First Affiliated Hospital, Sun Yat-Sen University