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Remote Ischemic Limb Preconditioning In Healthy Volunteers

Not Applicable
Completed
Conditions
Stroke
Cerebrovascular Disease
Registration Number
NCT02553655
Lead Sponsor
University of Miami
Brief Summary

The investigators would like to determine if remote ischemic leg preconditioning in healthy volunteers improves cerebral vasomotor reactivity as measured by breath holding and transcranial doppler vasomotor reactivity.

Detailed Description

This study is to determine if remote ischemic leg preconditioning improves short and long term cerebral vasomotor reactivity in healthy volunteers as measured by breath holding and transcranial doppler vasomotor reactivity. Previous studies on brachial vasomotor reactivity have shown a beneficial effect of remote ischemic preconditioning. It remains uncertain if a similar beneficial effect can be reproduced with cerebral vasomotor testing. Many biological mechanisms and effector pathways triggered by preconditioning have demonstrated endothelial protection and beneficial vascular effects.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
17
Inclusion Criteria
  • Healthy volunteers
Exclusion Criteria
  • Presence of chronic medical conditions such as diabetes, hypertension, cardiac disease etc.
  • Any prescribed medication
  • Pregnancy [by history and last menstrual period]
  • Any leg injury that would, in the opinion of the investigator, affect preconditioning

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Change in Vasomotor Reactivity to Carbon Dioxide (CO2)Baseline to 24 hours, Baseline to 48 hours

Change in vasomotor reactivity to carbon dioxide (CO2) or breath holding from baseline

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

University of Miami

🇺🇸

Miami, Florida, United States

University of Miami
🇺🇸Miami, Florida, United States

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