Remote Ischemic Limb Preconditioning In Healthy Volunteers
- Conditions
- StrokeCerebrovascular Disease
- Registration Number
- NCT02553655
- Lead Sponsor
- University of Miami
- Brief Summary
The investigators would like to determine if remote ischemic leg preconditioning in healthy volunteers improves cerebral vasomotor reactivity as measured by breath holding and transcranial doppler vasomotor reactivity.
- Detailed Description
This study is to determine if remote ischemic leg preconditioning improves short and long term cerebral vasomotor reactivity in healthy volunteers as measured by breath holding and transcranial doppler vasomotor reactivity. Previous studies on brachial vasomotor reactivity have shown a beneficial effect of remote ischemic preconditioning. It remains uncertain if a similar beneficial effect can be reproduced with cerebral vasomotor testing. Many biological mechanisms and effector pathways triggered by preconditioning have demonstrated endothelial protection and beneficial vascular effects.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 17
- Healthy volunteers
- Presence of chronic medical conditions such as diabetes, hypertension, cardiac disease etc.
- Any prescribed medication
- Pregnancy [by history and last menstrual period]
- Any leg injury that would, in the opinion of the investigator, affect preconditioning
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in Vasomotor Reactivity to Carbon Dioxide (CO2) Baseline to 24 hours, Baseline to 48 hours Change in vasomotor reactivity to carbon dioxide (CO2) or breath holding from baseline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Miami
🇺🇸Miami, Florida, United States
University of Miami🇺🇸Miami, Florida, United States