Does Remote Ischemic Limb Preconditioning Improve Cerebral Vasomotor Reactivity in Healthy Volunteers?
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cerebrovascular Disease
- Sponsor
- University of Miami
- Enrollment
- 17
- Locations
- 1
- Primary Endpoint
- Change in Vasomotor Reactivity to Carbon Dioxide (CO2)
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The investigators would like to determine if remote ischemic leg preconditioning in healthy volunteers improves cerebral vasomotor reactivity as measured by breath holding and transcranial doppler vasomotor reactivity.
Detailed Description
This study is to determine if remote ischemic leg preconditioning improves short and long term cerebral vasomotor reactivity in healthy volunteers as measured by breath holding and transcranial doppler vasomotor reactivity. Previous studies on brachial vasomotor reactivity have shown a beneficial effect of remote ischemic preconditioning. It remains uncertain if a similar beneficial effect can be reproduced with cerebral vasomotor testing. Many biological mechanisms and effector pathways triggered by preconditioning have demonstrated endothelial protection and beneficial vascular effects.
Investigators
Sebastian Koch
Professor of Clinical Neurology
University of Miami
Eligibility Criteria
Inclusion Criteria
- •Healthy volunteers
Exclusion Criteria
- •Presence of chronic medical conditions such as diabetes, hypertension, cardiac disease etc.
- •Any prescribed medication
- •Pregnancy \[by history and last menstrual period\]
- •Any leg injury that would, in the opinion of the investigator, affect preconditioning
Outcomes
Primary Outcomes
Change in Vasomotor Reactivity to Carbon Dioxide (CO2)
Time Frame: Baseline to 24 hours, Baseline to 48 hours
Change in vasomotor reactivity to carbon dioxide (CO2) or breath holding from baseline