Limb Remote Ischemic Preconditioning Reduces Heart and Lung Injury After Abdominal Aortic Aneurysm Repair:A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Abdominal Aortic Aneurysm
- Sponsor
- Cai Li
- Enrollment
- 62
- Primary Endpoint
- Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing elective open abdominal aortic aneurysm repair
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
To investigate whether limb remote ischemic preconditioning (LRIP) has protective effects against intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.
Detailed Description
Remote ischaemic preconditioning may confer the cytoprotection in critical organs. We hypothesized that limb remote ischemic preconditioning (RIPC) would reduce intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.The primary outcomes included the biomarkers reflecting intestinal injury (serum intestinal fatty acid binding protein, endotoxin levels and diamine oxidase activity) and the variables reflecting pulmonary injury (arterial-alveolar oxygen tension ratio, alveolar-arterial oxygen tension difference and respiratory index). In addition, the severity of intestinal and pulmonary injury was assessed with different scoring methods, respectively. Markers of oxidative stress and systemic inflammation were measured as well.
Investigators
Cai Li
Department of Anesthesiology,First Affiliated Hospital, Sun Yat-Sen University, Department of Anesthesiology,First Affiliated Hospital, Sun Yat-Sen University
First Affiliated Hospital, Sun Yat-Sen University
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of abdominal aortic aneurysm
- •Must be received open abdominal aortic aneurysm repair
Exclusion Criteria
- •age \>80 years old
- •Acute coronary syndrome or myocardial infraction within
- •Chronic obstructive pulmonary emphysema
- •angina pain within 48 hours of repair procedure
- •ejection fraction less than 40%
- •poor pulmonary function (PaO2 \<60mmHg)
- •history of inflammatory bowel disease
- •history of diarrhea (≥2 liquid stools per day for ≥2 days) within 1 week of surgery
- •intestinal chronic inflammatory disease
Outcomes
Primary Outcomes
Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing elective open abdominal aortic aneurysm repair
Time Frame: June,2011
Compared with the control group, patients in the LRIP group had significantly higher Cs and Cd , along with lower PA-aDO2 and RI at various phase (P\<0.05). Serum concentration of IL-6,IL-8, TNF-ɑ and MDA in LRIP group were decreased significantly at postoperative time points compared with those in control group (P\<0.05), but SOD was increased significantly at the same time (P\<0.05). Patient's ventilator support time and duration of ICU stay in LRIP group were shorter than that in control group (P\<0.05)