Biomarkers and rapid imaging in dementia diagnosis
- Conditions
- DementiaMental and Behavioural Disorders
- Registration Number
- ISRCTN12777415
- Lead Sponsor
- niversity of London
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 170
1. An individual with ability to engage in the decision to participate in the research study and provide informed consent
2. Aged 18 years old and above
Main study: Patients attending the CDC at NHNN and at Darent Valley Hospital who are due to have a standard-of-care MRI of the brain as part of their routine investigation.
Sub-study 1: Participants in other REC approved studies, who are scheduled for a planned MRI brain scan
Sub-study 2: Healthy controls recruited through spouses/partners of patients, individuals who are included on the DRC Research Register and Join Dementia Research and patients attending the CDC at NHNN and at Darent Valley Hospital
Sub-study 3: Participants recruited to the main study who are happy to be contacted about follow-up study procedures
1. Unable to tolerate a routine MRI scan plus a 7-minute fast-MRI scan
2. Unable to tolerate draw blood by venepuncture
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method on-inferiority of ultra-fast MRI compared to gold standard MRI assessed using a 5-point Likert<br>scale at baseline
- Secondary Outcome Measures
Name Time Method 1. Stability of ultra-fast MRI compared to gold standard MRI, assessed using a 5-point Likert scale at 2 weeks to 2 months<br>2. Ability of ultra-fast MRI to track longitudinal change compared to gold standard MRI, assessed using a 5-point Likert scale at 1 year<br>3. Blood biomarkers assessed by immunoassays at baseline, 2 weeks to 2-month interval and 1-year interval