eurological MRI-based biomarkers for treatment navigation in depressio

Recruiting

• Conditions: Major Depressive Disorder; mood disturbance; 10027946

• Registration Number: NL-OMON55072
• Lead Sponsor: Technische Universiteit Eindhoven

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 180

Inclusion Criteria

• Satisfy DSM-5 clinical criteria for MDD (Only acute and subacute duration
(0-2 years), for MDD group only)
• Unipolar depression (i.e. no bipolar disorder/mania, for MDD group only)
• Age: 18-65 (m/f)
• Willing and able to provide informed consent and agree that incidental
findings are reported

Exclusion Criteria

• Concurrent neurological disorders (e.g. epilepsy, stroke, head trauma, etc.)
• Current substance or alcohol abuse
• History of psychosis, bipolar depression, autism spectrum disorder, attention
deficit hyperactivity disorder or (mild) intellectual disability
• Contra-indication for MRI: implants, tattoos non-compatible with brain MRI,
pregnancy, claustrophobia
• Current or previous treatment with electroconvulsive therapy (ECT),
deep-brain stimulation (DBS) or transcranial magnetic stimulation (TMS)
• More than 3 depressive episodes in the past (for MDD group only)
• Has a current episode of MDD or ever had an MDD episode (for healthy control
group only)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified