NL-OMON50274RecruitingNot Applicable
The Effect of Leukocyte DNA mEthylation and micRoBIOME diversity and function on host defense mechanisms during community-acquired pneumonia. - ELDER-BIOME study
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 843
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •1) Age >= 18 y
- •2) Clinical suspicion of a new episode of acute respiratory tract infection
- •3) The presence of a new or increased infiltrate on chest radiography or
- •computed tomography (CT) or a positive SARS-CoV-2 PCR on nasopharyngeal swab
- •within 14 days prior to admission
- •4) Presence of two or more diagnostic clinical criteria:
- •- Production of purulent sputum or a change in the character of sputum
- •- Temperature >38°C or <36.1°C
- •- Auscultatory findings consistent with pneumonia, including rales,
- •evidence of pulmonary consolidation (dullness on percussion, bronchial breath
- •sounds, or egophony), or both
- •- Leukocytosis (>10×109 white cells per liter or >15% bands)
- •- C-reactive protein level of more than 3 times the upper limit of the
- •normal range
- •- Dyspnea, tachypnea, or hypoxemia
Exclusion Criteria
- •1) No informed consent is provided by patient
- •2) Patients who had recently been hospitalized (for >48 hours in the previous 2
- •weeks) or who resided in long-term care facilities
- •3) Patients with a colostomy
- •4) Patient is enrolled in an interventional clinical study of an anti-infective
- •or immunomodulatory therapy
Investigators
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