Determining the functional B cell response in patients with non-small cell lung cancer (NSCLC) through vaccination

niversity of Birmingham0 个研究点目标入组 40 人开始时间: 2019年7月2日最近更新: 2020年10月26日

适应症

试验速览

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•1. Patient is able to give informed consent and undertake the patient assessment as detailed in the protocol
•2. Patient has resectable NSCLC and be scheduled for surgical resection of the NSCLC from the time of baseline blood withdrawal OR has advanced disease NSCLC that is eligible for chemo/immunotherapy
•3. Patient is aged 65 or over OR patient is aged between 18 to 65 years AND have a long-term health condition such as COPD, diabetes, chronic kidney disease or liver disease, and therefore meeting standard of care requirements for PPSV23 vaccination

•1. Previously vaccinated with the PPSV23 vaccine in the last 5 years
•2. Oral steroids or other form of immunosuppression that will affect vaccine response
•3. Suppressed immune system caused by a health condition such as HIV
•4. Allergic to components of the study vaccines
•5. Suffering from an acute infective illness (as determined by the clinician at visit 2)

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