Investigation of the Effect of 8-week Controlled High Intense Interval Training in Type 2 Diabetic Patients

Not Applicable

Completed

• Conditions: Type 2 Diabetes
• Interventions: Other: Physical training

• Registration Number: NCT02333734
• Lead Sponsor: Aarhus University Hospital

Brief Summary

The overall objective of this study is to examine the blood flow in the thigh muscles and sugar metabolism before and after 8 weeks of high intensity interval training (HIIT) on a bicycle ergometer in patients with type 2 diabetes (T2D) and matched controls. The following parameters are included in the assessment:

* Sugar Metabolism

* Muscle and fat mass

* The blood flow at rest around the thigh muscles

* Oxygen uptake test on a bicycle ergometer and 5 km time trial

Detailed Description

Type 2 diabetes (T2D) can be defined as a bihormonal metabolic disorder characterised by insufficient insulin secretion and abnormal glucagon secretion. It is however well established that physical activity per se improves glucose and may postpone or even slow down in the diabetic population. Glycaemic control may be improved more by high intensity interval training than by intensities from existing recommended guidelines. Additionally, there seems to be accumulating evidence that high intensity interval training induces increased overall fat and abdominal fat mass loss as opposed to traditional continuous endurance training Therefore we hypothesise that 3 weekly sessions of high intensity interval training (10×60 sec. at an intensity inducing 90% of maximal heart frequency with a recovery of 60 sec. between each bout) over 8 weeks improves overall glycaemic control (glucose, insulin and glucagon), inflammatory status (interleukins, cytokines, chemokines and cell adhesion molecules) and blood flow (NO and PGI2 vasodilatory capabilities).

Study Timeline

• Study Start: 2014-07
• Study First Submitted: 2014-07-08
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Study First Submitted QC: 2015-01-06
• Study First Posted: 2015-01-07
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-02
• Last Update Posted: 2015-02-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

• Type 2 diabetes or matched healthy controls. T2D subject only : HbA1c > 7,3. All subjects have an age between 40-65 years and a body mass index between 25-40 kg/m2. Both genders is allowed

Exclusion Criteria

• Severe diseases /immobility

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Type 2 diabetic subjects	Physical training	Type 2 diabetic subjects physical training (interval training 3 times at week) in a period of 8 weeks.
Healthy subjects	Physical training	Healthy subjects physical training (interval training 3 times at week) in a period of 8 weeks.

Primary Outcome Measures

Name	Time	Method
Oral Glucose tolerance test (OGTT)	baseline and 8 weeks	Change from baseline and 8 weeks in glucose/insulin response from a 2.5 hours oral glucose tolerance test (iAUC) after 8 weeks training

Secondary Outcome Measures

Name	Time	Method
Physical fitness	baseline and 8 weeks	Change from baseline and after 8 weeks in physical fitness level (mL/min x kg) measured with submaximal test using a bicycle ergometer after 8 weeks interval training .

Trial Locations

Locations (1)

Aarhus Universityhospital, Aarhus University; 🇩🇰 Aarhus C, Denmark