Efficacy and Safety of Oral Cashew Nut Immunotherapy in Children (CAJESITO)
- Conditions
- Allergy;FoodAllergy, Nut
- Registration Number
- NCT05826405
- Lead Sponsor
- Central Hospital, Nancy, France
- Brief Summary
The objectives of the CAJESITO study are (i) to assess the tolerance of oral cashew nut immunotherapy, by describing the frequency and severity of allergic reactions during oral cashew nut immunotherapy and (ii )to assess the risk factors for severe allergic reactions during oral cashew nut immunotherapy (predictive factors, associated factors.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 40
- Patients under the age of 18 with a proven allergy to cashew nuts and followed in the pediatric allergology unit of the University Hospital of Nancy.
- Patients who have received oral cashew nut immunotherapy for at least 18 months as of 02/28/2023
- Patients who have received oral cashew nut immunotherapy for less than 18 months.
- Patients lost to follow-up for more than 3 years, i.e. last consultation dating from 2020 or earlier
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of allergic reaction during 6 months
- Secondary Outcome Measures
Name Time Method antibody variation during 6 months Modification of level of specific IgE and IGg4 with cashew nuts
sustained unresponsiveness 9 months Tolerance of 1, 2, 4, 8g in isolated doses and 15g in total cumulative dose of cashew nuts during an oral challenge test with cashew nuts 3 months after stopping the daily consumption of 2g of cashew nuts
oral tolerance of pistachio 6 months Tolerance of 1, 2, 4, 8g in isolated doses and 15g in total cumulative dose of pistachio during an oral provocation test with pistachio 3 months after stopping the daily consumption of 2g of cashew nuts
Predictive factor of good tolerance 6 months initial specific IgE and Ana o3 levels