LEft Atrial Pacing in Diastolic Heart Failure

Not Applicable

Completed

• Conditions: Atrial Dyssynchrony Syndrome; Left Atrio-ventricular Asynchrony; Heart Failure With Preserved Ejection Fraction
• Interventions: Procedure: pace make active/inactive cross over

• Registration Number: NCT01618981
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

The purpose of this study is to assess left atrial pacing therapy in patients with atrial dyssynchrony syndrome and heart failure with preserved ejection fraction.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-06-07
• Study First Submitted QC: 2012-06-13
• Study First Posted: 2012-06-14
• Study Start: 2012-11
• Primary Completion: 2016-04
• Study Completion: 2016-04
• Status Verified: 2018-12
• Last Update Submitted: 2018-12-26
• Last Update Posted: 2018-12-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Age ≥ 65
• Sinus rhythm, PR < 220ms, QRS < 110ms
• Heart failure (NYHA class III-IV or II with hospitalization for heart failure)
• Ejection Fraction > 50%, restrictive mitral inflow, Lateral E/e' > 12 or septal E/e' > 15, Left atrial index volume > 34 ml/m²
• Atrial dyssynchrony syndrome: (TTE) inter-atrial time delay ≥ 70ms (difference between tricuspid and mitral P-A intervals or between mitral and tricupsid P-A' intervals with DTI)
• Left atrio-ventricular asynchrony: Time Difference between tricupsid and mitral A wave duration ≥ 35ms.

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
first inactive	pace make active/inactive cross over	-
first active	pace make active/inactive cross over	-

Trial Locations

Locations (1)

CHU Dijon; 🇫🇷 Dijon, France