Angioplasty with Stent in Symptomatic Intracranial Stenosis Trial-II

The Ministry of Health of the People's Republic of China0 个研究点目标入组 399 人开始时间: 2005年10月4日最近更新: 2015年1月13日

试验速览

暂无简介。

•1. 18-75 years of age
•2. =1 major atherosclerotic risk factors (arterial hypertension, hyperlipidemia, diabetes mellitus, hyperhomocystinemia and smoking)
•3. Recurrent ischemic events (transient ischemic attack [TIA] and/or stroke) attributed to an intracranial stenosis =50% at digital subtraction angiography (DSA)
•4. Evidence of perfusion deficit at the territory referable to the target stenosis in computed tomography (CT)-perfusion
•5. The diameters of the parent arteries were between 2.0 to 4.0 mm, and length of stenoses <12 mm
•6. Modified Rankin score =2 prior to last ischemic event

•1. Stenosis of non-atherosclerotic origin (for example, vasculitis, Moya Moya disease and fibromuscular dysplasia)
•2. Intracranial hemorrhage and major ischemic stroke (National Institutes of Health-Stroke-Scale [NIHSS] =8) in the same hemisphere as the target lesion within 6 weeks
•3. A potential source of cardiac embolism
•4. Concurrent intracranial tumors, cerebral arteriovenous malformation (AVM) and aneurysms
•5. Presence of a neurological illness that can confound the diagnosis of TIA or stroke
•6. Known contraindication to aspirin, clopidogrel, probucol, heparin, stainless steel, anesthesia, or X-ray contrast
•7. Uncorrectable bleeding diathesis; previous stenting of the target artery
•8. A positive pregnancy test
•9. Life expectancy <1 year because of other medical conditions
•10. Patients were not eligible if they could not cooperate with the study procedures or provide informed consent

发起方

The Ministry of Health of the People's Republic of China