NCT00909129已完成不适用
Hepatitis C Virus Dynamic and Immune Activation in HIV-1 Coinfected Patients Treated With Pegylated Interferon Alfa-2a and Ribavirin
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Sustained virological response
研究概览
简要总结
The purpose of this study is to investigate T-cell mediated immune responses to HIV-1 and HCV and determine how these responses are affected by HCV treatment and correlates to response. Furthermore, to study Interferon-inducible protein-10 (IP-10) dynamics during HCV treatment, and correlate this to treatment outcome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HIV-1 Hepatitis C coinfected adult patients
- •Hepatitis C treatment naive
- •Stable HIV-1 infection with or without cART
- •> 300 CD4+ cell count
排除标准
- •Decompensated liver disease
- •Ongoing depression
- •Ongoing drug abuse
- •Other contraindications for interferon or ribavirin treatment
研究组 & 干预措施
HIV-1 HCV coinfected patients
Experimental
HIV-1 HCV coinfected patients undergoing HCV therapy
干预措施: pegylated interferon-alpha (Pegasys) (Drug)
HIV-1 HCV coinfected patients
Experimental
HIV-1 HCV coinfected patients undergoing HCV therapy
干预措施: ribavirin (COPEGUS) (Drug)
结局指标
主要结局
Sustained virological response
时间窗: 24 weeks end of treatment (EOT)
次要结局
- T-cell mediated immune responses(baseline to 24 weeks EOT)
研究者
研究点 (1)
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