Neuroplasticity in Adulthood: Physical Exercise and Cognitive Training; Integrative Omics Study on the Neurobiological Effects of Physical Activity and Cognitive Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 2
- 主要终点
- Changes in functional and structural brain plasticity assessed with Magnetic Resonance Imaging
研究概览
简要总结
The MoveMent project applies non-pharmacological strategies - physical exercise and cognitive training - that have been shown to be effective in promoting active and healthy aging. The objective is to study the molecular and neural mechanisms of these strategies to stimulate brain plasticity and improve brain health and cognitive functioning.
详细描述
It is a randomized controlled study with three intervention groups - physical, cognitive and combined - and a control group. The intervention is carried out over 3 months, with a frequency of 5 weekly sessions of 45 minutes each. Cognitive training is applied through a computerized program, physical training consists of a walking aerobic program, and combined training arises from the addition of the two previous ones.
140 participants will undergo an exhaustive pre- and post-intervention evaluation that includes neuropsychological, neuroimaging, genetic and biochemical analysis before and after the intervention as well as physical and health status assessment.
The present project aims to examine the independent and combined effects of exercise and cognitive stimulation in functional and structural brain plasticity, cognitive performance, emotional state and quality of life, and will determine the demographic and clinical factors that can modulate neuroplasticity. It will allow us to study the neurophysiological mechanisms by which the different types of intervention have an effect on the structure and functioning of the brain and cognition within an omics framework.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 50 and 70
- •Underactive or sedentary (<2 hours a week of physical activity).
- •Adequate visual, auditory and fine motor skills.
- •Able to speak and understand Catalan or Spanish language.
- •Accept to take part in the study and sign the informed consent according to the Declaration of Helsinki.
排除标准
- •Mini mental State examination < 24 and Montreal Cognitive Assessment- Short (MoCA -S) <
- •Diagnosis of mild cognitive impairment, dementia or other serious neurological, psychiatric, or systemic illness.
- •Presence of another illness that render them unable to engage in physical activity (signs or symptoms of chronic heart disease, chronic obstructive pulmonary disease, orthopedic problems).
- •History of drug abuse or alcoholism.
- •Psychotropic consumption
- •Contraindication to magnetic resonance imaging
研究组 & 干预措施
Physical exercise (n= 40)
Walking program up to 45 minutes, 5 times a week for 3 months.
干预措施: Physical exercise (Behavioral)
Cognitive training (n=40)
Computerized cognitive training up to 45 minutes, 5 times a week for 3 months.
干预措施: Cognitive training (Behavioral)
Combined training (n=40)
Exercise and cognitive training up to 90 minutes, 5 times a week for 3 months.
干预措施: Combined training (Behavioral)
Control group (n=20)
Waiting list group.They receive no intervention during this waiting period. At the end of this period our training programs are available to them.
结局指标
主要结局
Changes in functional and structural brain plasticity assessed with Magnetic Resonance Imaging
时间窗: Baseline and 3 months
Resting state connectivity, structural connectivity, white matter integrity, tractography, volume of white and grey matter structures.
次要结局
- Changes in cognitive function(Baseline and 3 months)
- Changes in emotional and functional status: Cognitive decline(Baseline and 3 months)
- Changes in emotional and functional status: Depression(Baseline and 3 months)
- Changes in emotional and functional status: Mood(Baseline and 3 months)
- Changes in emotional and functional status: Clinical outcome(Baseline and 3 months)
- Changes in health, fitness and physical activity: Cardiovascular risk factors(Baseline and 3 months)
- Changes in health, fitness and physical activity: Sleep(Baseline and 3 months)
- Changes in health, fitness and physical activity: Physical activity questionnaire(Baseline and 3 months)
- Changes in health, fitness and physical activity: Fitness(Baseline and 3 months)
- Changes in health, fitness and physical activity: Physical activity monitoring(Baseline and 3 months)
- Changes in metabolites and gene expression patterns(Baseline and 3 months)
研究者
Maria Mataro Serrat
PhD. Associate professor
University of Barcelona