Exercise, Cognitive Function and Neuroplasticity in Healthy Adults

Not Applicable

Completed

• Conditions: Sedentary Lifestyle
• Interventions: Behavioral: Moderate intensity exercise.; Behavioral: High intensity exercise.

• Registration Number: NCT02994134
• Lead Sponsor: University of Miami

Brief Summary

The overall goal of the proposed study is to compare the effects of 4 weeks of moderate or high intensity aerobic exercise on neuroplasticity, cognitive performance and gait and postural control in sedentary healthy adults.

Detailed Description

The primary aim of the study is to compare the effects of a moderate intensity aerobic exercise intervention (delivered at 55-64% age-predicted maximal heart rate) with a high intensity aerobic exercise intervention (delivered at 65%-90% age-predicted maximal heart rate) on measures that probe cortical synaptic plasticity using transcranial magnetic stimulation (TMS) in sedentary healthy adults.

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study First Submitted: 2016-12-01
• Study First Submitted QC: 2016-12-12
• Study First Posted: 2016-12-15
• Study Start: 2017-09-29
• Primary Completion: 2021-01-21
• Study Completion: 2021-10-31
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-24
• Last Update Posted: 2021-12-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

• Adult males and females aged 18-70 years old
• Primary language is English
• Sedentary (defined as not engaging in purposeful physical activity more than 2 times over the last two months)
• Exercise clearance

Read More

Exclusion Criteria

• Presence of cognitive, neurologic or orthopedic conditions that could affect performance of the testing and training procedures

• History of migraines.

• History of fainting spells of unknown or undetermined etiology that might constitute seizures

• History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistant epilepsy

• Any current history of a psychiatric illness

• Any unstable medical condition

• No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following:

  • The subject's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination with other CNS active drugs.
  • The published TMS guidelines review medications to be considered with TMS (Rossi, Hallett, Rossini, Pascual-Leone, & Safety of TMS Consensus Group, 2009).

• Any metal in the brain, skull or elsewhere unless approved by the responsible MD

• Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator)

• Intracranial lesion

• Substance abuse or dependence within the past six months Subjects who, in the Investigator's opinion, might not be suitable for the study

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Moderate intensity exercise.	Moderate intensity exercise.	Moderate intensity aerobic exercise intervention (delivered at 55-64% age-predicted maximal heart rate), 4 times per week for 4 weeks.
High intensity exercise	High intensity exercise.	High intensity aerobic exercise intervention (delivered at 65%-90% age-predicted maximal heart rate), 4 times per week for 4 weeks.

Primary Outcome Measures

Name	Time	Method
Change in cortical synaptic plasticity using transcranial magnetic stimulation (TMS) from baseline to post-exercise.	Baseline, 4 weeks	Plasticity with TMS

Trial Locations

Locations (1)

University of Miami Miller School of Medicine; 🇺🇸 Miami, Florida, United States