Impact of Exercise on Cognitive Impairment in End-Stage Renal Disease

University of Kansas Medical Center1 site in 1 country20 target enrollmentMay 2014

ConditionsCognitive Impairment End-Stage Renal Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Cognitive Impairment
Sponsor: University of Kansas Medical Center
Enrollment: 20
Locations: 1
Primary Endpoint: Feasibility
Status: Terminated
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to evaluate the impact of 12 weeks of exercise on cognition in patients with end stage renal disease.

Detailed Description

Patients with end stage renal disease have higher cognitive impairment than general population. They also have decreased physical and functional capacity. Exercise has shown to improve cognition in general population. This study will evaluate if exercise improves cognition in dialysis patients. It will also evaluate whether exercise affects performance in daily activities, mood or depression and inflammatory markers in the blood.

Registry

clinicaltrials.gov

Start Date

May 2014

End Date

December 2017

Last Updated

7 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Kansas Medical Center

Responsible Party

Principal Investigator

Aditi Gupta, MD

Assistant Professor

University of Kansas Medical Center

Eligibility Criteria

Inclusion Criteria

•Patients with ESRD on dialysis
•Age greater than 20 years
•Have means of transportation to and from the exercise session
•Speak English (as the neuropsychological tests will be performed in English)

Exclusion Criteria

•Recent myocardial infarction (within 6 weeks), unstable angina, uncontrolled arrhythmias, congestive heart failure (\> NYHA grade II)
•History of stroke in the last 2 months
•Active respiratory disease
•Uncontrolled hypertension
•Severe uncontrolled diabetes
•Persistent predialysis hyperkalemia
•Active decompensated liver disease
•Symptomatic peripheral vascular disease
•Musculoskeletal abnormalities that will be prohibit their participation in the exercise program
•Health conditions needing frequent hospitalizations

Outcomes

Primary Outcomes

Feasibility

Time Frame: Up to 26 Weeks

Subject compliance with exercise training

Secondary Outcomes

Markers of inflammation(Baseline, within 1 week before and within 1 week after exercise intervention)
Cognitive function(Baseline, within1 week before and within 1 week after exercise intervention)