NCT01995110已完成不适用
Identification of Nutritional Health Biomarkers for Metabolic Flexibility in Blood - a Randomized, Postprandial, Caloric Dose-response Strategy
Agroscope Liebefeld-Posieux Research Station ALP4 个研究点 分布在 1 个国家目标入组 14 人开始时间: 2011年3月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 14
- 试验地点
- 4
- 主要终点
- blood cell transkriptome/ gene-expression
研究概览
简要总结
The study will quantitatively evaluate the metabolic response of normal weight and obese subjects to three high-fat meals differing in caloric dose by analysing the postprandial blood transcriptome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •for normal weight subjects:
- •* age 25-50
- •* waist circumference \<94cm
- •Inclusion Criteria for obese subjects:
- •* age 25-50
- •* waist circumference \>102cm
排除标准
- •for both groups:
- •physiological or psychological diseases
- •allergies to food or intolerance to high-fat meal
- •vegetarians, vegans
- •chronic intake of drugs
- •diabetes mellitus type I and II
- •debiliating kidney disease
- •debiliating liver disease
- •clinically established coronary heart diseases
- •ingestion of vitamins or dietary supplements during the course of the study
结局指标
主要结局
blood cell transkriptome/ gene-expression
时间窗: 0h, 2h, 4h, 6h
* differently expressed genes between normal weight and obese subjects at baseline * changes in gene-expression 2, 4 and 6h after consumption
次要结局
未报告次要终点
研究者
研究点 (4)
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