Effect of Ventilation Mode on Lung Deposition of a Radiolabeled Aerosol During Mechanical Ventilation: Barometric Versus Volumetric
Overview
- Phase
- Not Applicable
- Intervention
- Gamma scintigraphy
- Conditions
- Post-operative Neurosurgery
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Enrollment
- 19
- Locations
- 1
- Primary Endpoint
- Pulmonary deposition
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Controlling the respiratory pattern of mechanically ventilated patients in volume control mode is recommended during nebulization. No studies looked into conditions of nebulization during assisted mechanical ventilation to define the optimal nebulization technique and its effect on pulmonary deposition.
The aim of this study is to analyse the effect of ventilation mode (barometric versus volumetric) on deposition by planar scintigraphy during mechanical ventilation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Invasive mechanical ventilation
- •Healthy lungs
Exclusion Criteria
- •Change of ventilation mode during nebulization
Arms & Interventions
Nebulization during volume assist control mode
Patients ventilated in volume assist control mode during nebulization
Intervention: Gamma scintigraphy
Nebulization during volume assist control mode
Patients ventilated in volume assist control mode during nebulization
Intervention: Preoperative spirometry
Nebulization during pressure support ventilation
Patients ventilated in pressure support mode during nebulization
Intervention: technetium-99m - Diethylenetriaminepentaacetic acid
Nebulization during pressure support ventilation
Patients ventilated in pressure support mode during nebulization
Intervention: Vibrating-mesh nebulizer
Nebulization during pressure support ventilation
Patients ventilated in pressure support mode during nebulization
Intervention: Gamma scintigraphy
Nebulization during pressure support ventilation
Patients ventilated in pressure support mode during nebulization
Intervention: Preoperative spirometry
Nebulization during volume assist control mode
Patients ventilated in volume assist control mode during nebulization
Intervention: technetium-99m - Diethylenetriaminepentaacetic acid
Nebulization during volume assist control mode
Patients ventilated in volume assist control mode during nebulization
Intervention: Vibrating-mesh nebulizer
Outcomes
Primary Outcomes
Pulmonary deposition
Time Frame: Immediately after nebulization by imaging assessment, an expected average of 30 minutes
Secondary Outcomes
- Penetration index(Immediately after nebulization by imaging assessment, an expected average of 30 minutes)
- Lung function(Preoperative assessment, the day before inclusion)
- Mechanical ventilation settings(During nebulisation time, an expected average of 15 minutes)