Effect of mechanical ventilation and alveolar recruitment on post operative pulmonary complications and lung mechanics in patients - Undergoing cardiopulmonary bypass : A prospective interventional study

izams institute of medical sciences0 个研究点目标入组 0 人开始时间: 待定最近更新: 2022年8月2日

试验速览

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•1) AGE >18years
•2) Elective cardiac surgery
•3) Surgical intervention performed with CPB, aortic cross-clamping 4) Valvular surgery, coronary surgery, surgery on the ascending aorta 5) Median sternotomy and bi-pulmonary ventilation

•1) Patient refusal
•2) Non elective cardiac surgery
•3) Previous cardiac surgery
•4) Anticipated circulatory arrest.
•5) Patients with BMI >30
•6) Patients with end-stage chronic kidney disease (defined as need for dialysis) 7) Patients with known respiratory diseases (ongoing respiratory infections, asthma, COPD, OSAS)
•8) Patients already intubated before arrival in operating theatre
•9) Previous pulmonary resection
•10) Patients with a preoperative oxygen saturation <90%, or Pa O2 < 60 mmHg without supplemental oxygen, or a PaO2 /FiO 2 ratio <300, or PaCO 2 > 45 mmHg
•11) Patients with hepatic disease, defined as elevated liver enzymes (higher than two reference intervals)
•12) Patients with pulmonary hypertension (defined as preoperative estimated systolic pulmonary artery pressure >55 mmHg)

发起方

izams institute of medical sciences