Evaluation of Efficacy of Peripheral Nerve Blocks as an add on therapy to Carbamazepine in Trigeminal Neuralgia A Randomized control Trial
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- 1.Numeric Pain Rating Scale (NPRS) assessment of pain
研究概览
简要总结
Trigeminal neuralgia is a chronic type of neuropathic pain characterized by paroxysmal electric shock like pain that affects the individuals quality of life to a great extent Carbamazepine being the first line of drug for trigeminal neuralgia is primarily prescribed to the patient But due to its vast number of side effects it Is not well tolerated by the patient as dose increases Since it Is an excruciating pain condition there is need to explore more treatment modalities helping in attaining better pain relief There are few studies regarding use of Peripheral Nerve Blocks and Trigger zone injections with local anaesthetics along with routine drug therapy in refractory cases of Trigeminal Neuralgia patients with good results Its efficacy has been established in acute exacerbations of Trigeminal Neuralgia Lignocaine is being widely used in dentistry in topical as well as injectable form to treat several acute and chronic pain conditions with minimal adverse effects Performing lignocaine nerve blocks is a routine in office procedure in dental clinics More over to the best of our knowledge till now no studies have evaluated the therapeutic effectiveness and synergistic effect of 2 percent Lignocaine nerve blocks in routine management of Trigeminal Neuralgia patients The aim of the present study is to bridge that gap in literature and to evaluate the efficacy of this multimodal treatment strategy in trigeminal neuralgia patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 35.00 Year(s) 至 85.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients diagnosed with Classical and Idiopathic Neuralgia Newly diagnosed Trigeminal Neuralgia patients or with remission of 1 months or more Patient consent for participation in this study.
排除标准
- •Secondary Trigeminal Neuralgia patients Patients on anti psychotics History of excessive alcohol intake Hepatic or renal insufficiency Known tolerance or allergy to study drug Pregnancy or Lactation Non compliant during screening period.
结局指标
主要结局
1.Numeric Pain Rating Scale (NPRS) assessment of pain
时间窗: 0 1 2 3 weeks 1 month 3 months
次要结局
- 1 To evaluate mean dose of carbamazepine used in both the groups(2 To evaluate number of responders with 50 percent relief in pain.)