Does Low-Dose Aspirin Improve Outcome in In Vitro Fertilisation/Intra Cytoplasmatic Sperm Injection (IVF/ICSI)?

Phase 3

Completed

• Conditions: Infertility
• Interventions: Drug: placebo; Drug: aspirin

• Registration Number: NCT00644085
• Lead Sponsor: University Hospital, Ghent

Brief Summary

To investigate the effect of daily administration of low-dose aspirin, compared to placebo, on IVF and ICSI outcome.

Detailed Description

Not available

Study Timeline

• Study Start: 2000-04
• Study Completion: 2007-12
• Status Verified: 2008-03
• Study First Submitted: 2008-03-20
• Study First Submitted QC: 2008-03-25
• Study First Posted: 2008-03-26
• Last Update Submitted: 2008-03-26
• Last Update Posted: 2008-03-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 201

Inclusion Criteria

• Dutch-speaking women
• Starting a first or second IVF/ICSI cycle

Exclusion Criteria

• Women suffering from

  • platelet dysfunction
  • thrombopenia
  • gastro-intestinal ulcers
  • recurrent gastritis
  • aspirin hypersensitivity

• Women on treatment with anticoagulants or aspirin

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2	placebo	oral administration of placebo
1	aspirin	oral administration of aspirin 100 mg

Primary Outcome Measures

Name	Time	Method
Number of oocytes retrieved
Clinical pregnancy rate per embryo transfer

Secondary Outcome Measures

Name	Time	Method
Live birth rate per cycle

Trial Locations

Locations (1)

University Hospital Ghent; 🇧🇪 Ghent, Belgium