Low-Dose Aspirin in in Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) Treatments
- Conditions
- Miscarriage Less Than 12 Gestational WeeksPreeclampsiaExtrauterine PregnancyPregnancyIntrauterine Fetal Growth Restriction
- Interventions
- Drug: Placebo
- Registration Number
- NCT00683202
- Lead Sponsor
- University of Oulu
- Brief Summary
In this study we hypothesized that low-dose aspirin therapy (100 mg daily) improves ovarian responsiveness, uterine haemodynamics and clinical pregnancy rates in unselected subjects undergoing IVF/ICSI when the treatment is started concomitantly with controlled ovarian hyperstimulation.
- Detailed Description
Low-dose acetylsalicylic acid irreversibly inhibits the cyclo-oxygenase enzyme in platelets, thus preventing the synthesis of thromboxane, which causes vasoconstriction and platelet aggregation. By this mechanism low-dose aspirin may enhance ovarian and uterine blood flow and tissue perfusion and thus improve ovarian responsiveness for gonadotrophins and endometrial receptivity for implantation. Randomized controlled studies and meta-analyses on the low-dose aspirin therapy to improve IVF/ICSI outcome or uterine hemodynamics have revealed conflicting results.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 374
- age < 40 years
- < 4 previous ovarian stimulations
- allergy for acetylsalicylic acid
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 Placebo Placebo daily perorally 1 Acetylsalicylic acid Acetylsalicylic acid 100 mg daily perorally
- Primary Outcome Measures
Name Time Method Pregnancy rate Five weeks after embryo transfer
- Secondary Outcome Measures
Name Time Method Uterine artery and spiral artery pulsatility index values On the day of embryo transfer
Trial Locations
- Locations (1)
University Hospital of Oulu, Department of Obstetrics and Gynecology
🇫🇮Oulu, Finland