Effect of Physical Activity Pattern on Cardiometabolic Health
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- glucose level
研究概览
简要总结
The goal of this study is to understand the interaction between the circadian system and physical activity.
Participants will:
- complete 2 inpatient stays
- perform moderate exercise
- be provided with identical meals
- have frequent blood draws
- provide urine and saliva samples
详细描述
The endogenous circadian system (i.e., an internal biological rhythm) plays an important role in regulating blood glucose, blood pressure, and energy expenditure. Physical activity improves health and reduces the risk for cardiovascular diseases and type 2 diabetes. The goal of this study is to understand the interaction between the circadian system and physical activity. We aim to test whether such relationship between the circadian system and physical activity can be used to enhance the health benefits of physical activity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-45 yr old
- •Body mass index (BMI) 18.5 - 34.9 kg/m2
- •No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
- •Willing to adhere to the protocol requirements for the duration of the study
排除标准
- •Currently smoking/vaping or 5 or more years of smoking/vaping
- •Currently pregnant or breastfeeding
- •History of drug or alcohol dependency
- •History of psychiatric illness or disorder
- •Any hospitalization due to COVID-19
- •Inability to exercise for any reason
- •Any known contraindication to exercise testing based on current ACSM guidelines
结局指标
主要结局
glucose level
时间窗: 24-hour test period after exercise
mean glucose level after exercise session
mean arterial pressure
时间窗: 24-hour test period after exercise
mean arterial pressure after exercise session
次要结局
- total peripheral resistance(24-hour test period after exercise)
- autonomic nervous system activity(24-hour test period after exercise)
- insulin sensitivity index(about 12 and 24 hours after exercise)
- beta-cell function index(about 12 and 24 hours after exercise)
研究者
Jingyi Qian
Investigator
Brigham and Women's Hospital