Effect of Physical Activity Pattern on Cardiometabolic Health
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Life Style
- Sponsor
- Brigham and Women's Hospital
- Enrollment
- 26
- Locations
- 1
- Primary Endpoint
- glucose level
- Status
- Recruiting
- Last Updated
- 10 months ago
Overview
Brief Summary
The goal of this study is to understand the interaction between the circadian system and physical activity.
Participants will:
- complete 2 inpatient stays
- perform moderate exercise
- be provided with identical meals
- have frequent blood draws
- provide urine and saliva samples
Detailed Description
The endogenous circadian system (i.e., an internal biological rhythm) plays an important role in regulating blood glucose, blood pressure, and energy expenditure. Physical activity improves health and reduces the risk for cardiovascular diseases and type 2 diabetes. The goal of this study is to understand the interaction between the circadian system and physical activity. We aim to test whether such relationship between the circadian system and physical activity can be used to enhance the health benefits of physical activity.
Investigators
Jingyi Qian
Investigator
Brigham and Women's Hospital
Eligibility Criteria
Inclusion Criteria
- •18-45 yr old
- •Body mass index (BMI) 18.5 - 34.9 kg/m2
- •No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
- •Willing to adhere to the protocol requirements for the duration of the study
Exclusion Criteria
- •Currently smoking/vaping or 5 or more years of smoking/vaping
- •Currently pregnant or breastfeeding
- •History of drug or alcohol dependency
- •History of psychiatric illness or disorder
- •Any hospitalization due to COVID-19
- •Inability to exercise for any reason
- •Any known contraindication to exercise testing based on current ACSM guidelines
Outcomes
Primary Outcomes
glucose level
Time Frame: 24-hour test period after exercise
mean glucose level after exercise session
mean arterial pressure
Time Frame: 24-hour test period after exercise
mean arterial pressure after exercise session
Secondary Outcomes
- total peripheral resistance(24-hour test period after exercise)
- autonomic nervous system activity(24-hour test period after exercise)
- insulin sensitivity index(about 12 and 24 hours after exercise)
- beta-cell function index(about 12 and 24 hours after exercise)