To study ventricular functions of the heart in late onset sepsis of newborn infants by echocardiography
Not Applicable
- Conditions
- Health Condition 1: P399- Infection specific to the perinatal period, unspecified
- Registration Number
- CTRI/2023/10/058967
- Lead Sponsor
- Bharati Vidyapeeth Deemed University Medical College, Pune
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Term and preterm neonates admitted to NICU during the study period and clinically suspected to have late onset sepsis ( onset after 72 hours of life)
Exclusion Criteria
1. Moderate to severe hypoxic ischemic encephalopathy with pH <7 at birth or APGAR less than 5 at 5 mins
2. Congenital heart disease
3. Major congenital malformations
4. Neonates on inotropic support or received inotropes in last 24 hours at the time of enrolment
5. Haemodynamically significant patent ductus arteriosus
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To measure myocardial performance index using targeted echocardiography in neonates with clinically suspected late onset sepsis and determine its association with proven and probable sepsisTimepoint: as soon as possible after the onset of clinical signs of sepsis and before initiation of fluid resuscitation/ inotropic support if required
- Secondary Outcome Measures
Name Time Method 1)To determine the correlation between myocardial performance index and C-Reactive Protein (CRP) in neonates with late onset sepsis <br/ ><br>2)To determine association of myocardial performance index and outcomes such as inotropic support, duration of hospital stay, mortality in neonates with late onset sepsis <br/ ><br>3)To measure other right and left ventricular functions in neonates with suspected late onset neonatal sepsis and determine their association with late onset sepsis <br/ ><br>Timepoint: as soon as possible after the onset of clinical signs of sepsis and before initiation