Descriptive Study on MRI Contrast of Acute Cerebral Hemorrhage in Different Microangiopathies
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 128
- 试验地点
- 1
- 主要终点
- Presence of spot sign on gadolinium MRI
研究概览
简要总结
Cerebral haemorrhage represents a minority of acute vascular syndromes (less frequent than ischemic stroke, at around 20%), but with a therapeutic impasse, having no specific treatment.
Arterial contrast ("spot sign") within the hematoma has been described in CT scans as a risk factor for further enlargement and poor prognosis.
An equivalent marker has also been described in gadolinium-enhanced MRI.
By studying the radiological appearance of gadolinium "spot signs" on MRI, which has better parenchymal resolution, the researchers propose to retrace the phenomenology of the acute phase of cerebral hemorrhage in order to better estimate the risk of radiological aggravation by subgroup, which could serve as a target population for future therapeutic trials.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with acute cerebral hematomas from existing databases of cerebral amyloid angiopathy and hypertensive microangiopathy managed at Nîmes University Hospital;
- •Patients who have undergone a follow-up cerebral CT scan in the event of worsening or for follow-up.
排除标准
- •Patient refusing to participate
研究组 & 干预措施
patients with acute lobar and deep haematoma
None, pure observational study
干预措施: None, pure observational study (Other)
结局指标
主要结局
Presence of spot sign on gadolinium MRI
时间窗: baseline
Presence of spot sign on gadolinium MRI (Yes/No)
Morphologic description of gadolinium MRI spot sign
时间窗: baseline
morphological (shape, location within the hematoma) description of spot signs on brain MRI
Quantitative description of gadolinium MRI spot sign
时间窗: baseline
Quantitative (number and categorial) description of spot signs on brain MRI
次要结局
- association of spot sign with hematoma expansion on follow-up CT(Baseline)
- Association with the underlaying pathology(Baseline)