Early Detection of Lung Cancer Via Bi-plane Correlation Chest Imaging

Early Phase 1

Completed

• Conditions: Metastatic Cancer in the Lungs; Lung Cancer
• Interventions: Device: bi-plane chest radiography

• Registration Number: NCT00673283
• Lead Sponsor: Duke University

Brief Summary

This project proposes a new method, Bi-plane Correlation Imaging (BCI), for improved detection of subtle lung nodules. In BCI, two digital radiographs of the chest are acquired within a short time interval from slightly different posterior projections. The image data are incorporated into an enhanced Computer-aided Diagnosis (CAD) algorithm in which nodules present in the thoracic cavity are detected by examining the geometrical correlation of the detected signals in the two views. The data are alos viewed stereoscopically for visual diagnosis. The expected high sensitivity/specificity of the method has the potential to change the current state of practice, perhaps leading to a preventive lung cancer screening program for high-risk populations, similar to the mammography screening program currently in place for breast cancer.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-04
• Study First Submitted: 2008-05-04
• Study First Submitted QC: 2008-05-04
• Study First Posted: 2008-05-07
• Primary Completion: 2008-11
• Study Completion: 2008-11
• Status Verified: 2013-01
• Last Update Submitted: 2014-07-31
• Last Update Posted: 2014-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 86

Inclusion Criteria

• Normal individuals
• Individuals with CT-confirmed subtle lung nodules.

Exclusion Criteria

• Individuals with acute pulmonary abnormalities or those in poor health conditions will be excluded due to the potential impact on the results as well as difficulty of acquiring the images. Pregnant women will also be excluded to avoid the exposure of the fetus to radiation.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
A	bi-plane chest radiography	-

Primary Outcome Measures

Name	Time	Method
The technique is effective in diagnosing early lung tumors.	end of the study

Secondary Outcome Measures

Name	Time	Method
The relative performance of BCI with respect to chest radiography and CT for lung cancer detection.	end of the study

Trial Locations

Locations (1)

Duke University Medcal Center; 🇺🇸 Durham, North Carolina, United States