DRKS00008899招募中未知
Electrophysiological characterization of pathological oscillations in Basal-Ganglia-Cortex-Loops and their coupling to muscle activity in patients with Idiopathic Parkinson's disease during the performance of a tapping task. - InExPacT
AG für Bewegungsstörungen und Tiefe HirnstimulationKlinik und Poliklinik für Neurologie und PsychiatrieUniklinikum Köln0 个研究点目标入组 24 人开始时间: 2015年10月2日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomized controlled study
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 30 Years 至 80 Years（—）
- 性别
- All
入选标准
- •Healthy subjects:
- •Male and female participants between 30 and 80 years of age
- •Right handed persons
- •Capability of signing an informed consent
- •Parkinson’s patients:
- •Male and female patients with the diagnosis of an IPS according to the guidelines of the DGN
- •Right handed patients
- •positive motor response to L-Dopa or Apomorphine;
- •Patients between 30 and 80 (in order to exclude genetic variants of the disease);
- •time period of the symptomes longer than 4 years (differential diagnosis);
- •patients have to be able to sign an informed consent;
- •Ability to cooperate during the measurements
排除标准
- •Healthy subjects:
- •non- sui juris patients, underaged persons as well as subjects which are judically sent to an institution
- •diagnosis of an idiopathic parkinson syndrom or any other neurological disease
- •participants that take drugs regularly which influence the nervous system and which can not be stopped the evening before the experiment
- •severe internal comorbidities
- •presence of psychiatric diseases
- •impaired vision or hearing defect that may hinder the testing
- •pregnant or breast feeding mothers
- •Parkinson’s patients:
- •non- sui juris patients, underaged persons as well as subjects which are judically sent to an institution
- •patients that suffer from another neurological disease apart from Parkinsons like Epilepsy, Alzheimers or Dystonia
- •patients with severe frontal executive disturbances
- •presence of a Parkinson-Plus-Syndrom like corticobasal degeneration, progressive supranuclear palsy or multisystem atrophy
- •other hypokinetic movement disorders like MPTP- or manganese intoxication, chorea Huntington, subcortical arteriosclerotic encephalopathy or psychogenic movement disorder
- •clinically relevant abnormalities in preoperative MR-Images like ischemia, or cerebral athropy
- •previous surgeries in the ZNS due to, for example, brain tumors, epilepsy or vascular reasons
- •severe internal comorbidities
- •presence of psychiatric diseases
- •impaired vision or hearing defect that may hinder the testing
- •pregnant or breast feeding mothers
研究者
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