clinical profile of autonomic dysfunction and mechanical ventilation in Guillian Barre syndrome

Not Applicable

• Conditions: Health Condition 1: G00-G99- Diseases of the nervous system

• Registration Number: CTRI/2021/06/034242
• Lead Sponsor: I

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Patients with GBS, based on clinical, CSF and electro-diagnostic criteria will be included in this study.

GBS patients with clinical evidence (defined below) of sympathetic hyperactivity will receive prazosin and titrated as per patientâ??s requirement.

clinical evidence of sympathetic hyperactivity includes cold and clammy skin (after ruling out dehydration), presence of hypertension (SBP > 140/90 mmHg) for more than 2 hours with or without pulmonary edema or Labile BP (defined as BP differences of >40mmHg in a single day) or Resting Tachycardia ( > 125 beats per minute) for 2 hours.

Exclusion Criteria

Patients with hypo or hyperkalemic paralysis, toxins, porphyria, viral myositis, MND, Cervical myelopathy and CSF cell > 50/mm3 will be excluded.

GBS patients with Hypotension (systolic blood pressure < 90 mmHg) and bradycardia ( < 48 beats per minute) will also be excluded.

Study & Design

• Study Type: Observational
• Study Design: Not specified