Electrophysiological characterization of pathological oscillations in Basal-Ganglia-Cortex-Loops and their coupling to muscle activity in patients with Idiopathic Parkinson's disease during the performance of a tapping task.

Not Applicable

Recruiting

• Conditions: Healthy Subjects; G20; Parkinson disease

• Registration Number: DRKS00008899
• Lead Sponsor: AG für Bewegungsstörungen und Tiefe HirnstimulationKlinik und Poliklinik für Neurologie und PsychiatrieUniklinikum Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-10-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Healthy subjects:
• Male and female participants between 30 and 80 years of age
• Right handed persons
• Capability of signing an informed consent

Parkinson’s patients:
• Male and female patients with the diagnosis of an IPS according to the guidelines of the DGN
• Right handed patients
• positive motor response to L-Dopa or Apomorphine;
• Patients between 30 and 80 (in order to exclude genetic variants of the disease);
• time period of the symptomes longer than 4 years (differential diagnosis);
• patients have to be able to sign an informed consent;
• Ability to cooperate during the measurements

Exclusion Criteria

Healthy subjects:
• non- sui juris patients, underaged persons as well as subjects which are judically sent to an institution
• diagnosis of an idiopathic parkinson syndrom or any other neurological disease
• participants that take drugs regularly which influence the nervous system and which can not be stopped the evening before the experiment
• severe internal comorbidities
• presence of psychiatric diseases
•impaired vision or hearing defect that may hinder the testing
• pregnant or breast feeding mothers

Parkinson’s patients:
• non- sui juris patients, underaged persons as well as subjects which are judically sent to an institution
• patients that suffer from another neurological disease apart from Parkinsons like Epilepsy, Alzheimers or Dystonia
• patients with severe frontal executive disturbances
• presence of a Parkinson-Plus-Syndrom like corticobasal degeneration, progressive supranuclear palsy or multisystem atrophy
• other hypokinetic movement disorders like MPTP- or manganese intoxication, chorea Huntington, subcortical arteriosclerotic encephalopathy or psychogenic movement disorder
• clinically relevant abnormalities in preoperative MR-Images like ischemia, or cerebral athropy
• previous surgeries in the ZNS due to, for example, brain tumors, epilepsy or vascular reasons
• severe internal comorbidities
• presence of psychiatric diseases
• impaired vision or hearing defect that may hinder the testing
• pregnant or breast feeding mothers

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pathological coupling of motor related brain areas in Parkinson's patients compared to healthy subjects

Secondary Outcome Measures

Name	Time	Method
Parkinson's patients exhibit a stronger impairment for self initiated than externally triggered movements.