The Influences of Hypnotics or Sedatives on Aspiration Pneumonia and Hip Fracture in Community Dwelling Older Japanese Adults
- Conditions
- geriatrics
- Registration Number
- JPRN-UMIN000048398
- Lead Sponsor
- Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
- Brief Summary
RESULTS During 42 months of follow-up period, the incidences of aspiration pneumonia, hip fracture and mortality in hypnotics group were significantly increased compared with the control groups. Sensitivity analyses utilizing inverse probability weighing demonstrated Hazard ratio: 1.083 [1.023-1.146] in mortality, 1.117 [1.014-1.230] in aspiration pneumonia, 1.720 [1.559-1.897] in hip fracture. Meanwhile, attribute risk difference were 1.8, 1.5 and 1.0 per 1000 patient-year
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 66190
Not provided
Regular use of CNS drugs except hypnotics or sedatives (n=45309) History of hospital admission from 04/2016 to 09/2016 (n=86725) Chronic dialysis patients (n=2819) Certification of needed long term care (n=49019) The following diagnosis by the end of 09/2016 1. Malignant neoplasm (n=254284), 2. Dementia (n=10681) 3. Depression (n=13193) # There are overlapped subjects
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ew diagnoses of aspiration pneumonia, hip fracture, and all-cause mortality
- Secondary Outcome Measures
Name Time Method