Effect of Anesthesia Technique on Outcome After Hip Fracture Surgery in Elderly Adult Patients

Not Applicable

Completed

• Conditions: Hip Fracture
• Interventions: Drug: Desflurane; Drug: Propofol; Drug: Bupivacaine

• Registration Number: NCT02458547
• Lead Sponsor: Yonsei University

Brief Summary

Despite many previous studies, whether anesthetic technique will significantly affect overall patient outcome, morbidity and mortality in elderly hip fracture patients is controversial. Due to old age, poor patient condition and emergent clinical settings, patients undergoing surgical procedures for hip fracture management are often subject to poor postoperative outcome and high mortality rates. While many studies have reported that regional anesthesia leads to improved postoperative outcome after hip fracture surgery, others have concluded otherwise. Moreover, because the majority of these previous studies are retrospective cohorts or systemic reviews, there is a need for randomized clinical trials to provide high quality evidence. This study aims to compare patient outcome between three different anesthetic techniques in elderly patients undergoing surgery for hip fracture management by evaluating proinflammatory cytokines, chemistry lab testing and clinical outcome between general anesthesia with either desflurane or propofol-based TIVA and spinal anesthesia with bupivacaine.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-05
• Study First Submitted: 2015-05-26
• Study First Submitted QC: 2015-05-29
• Study First Posted: 2015-06-01
• Primary Completion: 2019-01-21
• Study Completion: 2019-01-21
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-15
• Last Update Posted: 2019-03-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 186

Inclusion Criteria

1. Patients older than 65 years scheduled for elective or emergency hip fracture surgery.

Exclusion Criteria

1. Patient refusal
2. Inflammation or wound at puncture site, increased intracranial pressure, bleeding diathesis
3. Allergies to propofol or its ingredients, soybeans or peanuts
4. Patients with altered mental status
5. Illiterate patients or foreigners

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group D	Desflurane	General anesthesia with desflurane
Group P	Propofol	General anesthesia with propofol total intravenous anesthesia
Group S	Bupivacaine	Spinal anesthesia with 0.5% bupivacaine

Primary Outcome Measures

Name	Time	Method
HMGB1	from preoperative baseline to 72hours
IL-6	from preoperative baseline to 72hours
NT-proBNP	from preoperative baseline to 72hours
hemoglobin	from preoperative baseline to 72hours
total lymphocyte count	from preoperative baseline to 72hours
albumin	from preoperative baseline to 72hours
creatinine	from preoperative baseline to 72hours
potassium	from preoperative baseline to 72hours
troponin-T	from preoperative baseline to 72hours
CRP	from preoperative baseline to 72hours

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University Health System; 🇰🇷 Seoul, Korea, Republic of