Heavy Bupivacaine Versus Plain Bupivacaine in Peribulbar Block
试验速览
- 阶段
- 4 期
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The onset and duration of lid and globe akinesia
研究概览
简要总结
Most of the ophthalmic procedures are performed under local anesthesia as the patient is often elderly and with diseases. This may increase the risk of morbidity and mortality under general anesthesia. Different eye blocks have been practiced with great success. Moreover, it is associated with less hemodynamic instability, less respiratory depression, better postoperative pain relief, and less nausea and vomiting than general anesthesia. It is also associated with a reduction in stress response, maintained oxygen saturation and cardiovascular stability, in addition to the production of good akinesia and anesthesia alleviating occulo-medullary reflexes, all make local anesthesia more superior and safe technique.
详细描述
Peribulbar anesthesia is widely practiced now as a safe local block for cataract eye surgeries. However, the limited duration of these blocks was shown to be the main problem encountered intra-operatively. Therefore, additional top-up doses are usually needed to continue the operation. Many kinds of research tried to introduce solutions in order to prolong the duration of the local anesthetics used. Many researchers tried different volumes, doses and adjuvant to local anesthetics, and studied their effects There are many studies that evaluated the effect of baricity of local anesthetic on the potency of motor block and the duration of motor and sensory blockade.
However, no properly designed randomized, controlled studies have evaluated the feasibility and reliability of baricity local anesthetic agents used for the peribulbar block.
Aim of the work prospective, randomized study was conducted to evaluate the effects of the baricitized bupivacaine used for the peribulbar block in patients undergoing posterior segment surgeries.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with American Society of Anesthesiology (ASA) I or II.
- •30-80 years old
- •Patients scheduled for elective unilateral posterior segment surgeries.
排除标准
- •Patient's refusal.
- •orbital deformity
- •axial length( >28 mm )
- •increased intraocular pressure, or if they were blind in the contralateral eye, international normalized ratio (INR) > 1.5
- •allergy to local anesthetics, mentally retarded patients
研究组 & 干预措施
hyperbaric bupvacaine group
Peribulbar block will be performed using a total volume of 7 ml 6ml hyperbaric bupivacaine 0.5% + hyaluronidase (50 IU) in 1ml saline
干预措施: hyperbaric bupvacaine in Peribulbar block (Drug)
isobaric bupvacaine group
Peribulbar block will be performed using a total volume of 7 ml 6ml isorbaric bupivacaine 0.5% + hyaluronidase (50 IU) in 1ml saline
干预措施: isobaric bupvacaine in Peribulbar block (Drug)
结局指标
主要结局
The onset and duration of lid and globe akinesia
时间窗: 12 hours postoperative
scoring the ocular movements in each direction of gaze
次要结局
未报告次要终点
研究者
Hassan Mohamed Ali
lecturer of anesthesia
Cairo University