aryngeal oxygen concentration and apnoea time during microlaryngeal surgery using transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) with different oxygen concentrations: A randomised controlled clinical trial

Not Applicable

• Conditions: Airway management during microlaryngeal surgery; Ventilation during general anaesthesia for microlaryngeal laser surgery; Anaesthesiology - Other anaesthesiology

• Registration Number: ACTRN12623000575639
• Lead Sponsor: Dr Liang Voice Program, The University of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-25
• Last Update Posted: 3 June 2024

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

Age > 18 years
- Elective microlaryngeal surgeries, including but not limited to the following procedures:
•Microlaryngoscopy with or without biopsy (MBS item number: 41855)
•Microlaryngoscopy with removal of laryngeal lesion (MBS item number: 41861)
•Microlaryngoscopy with removal of lesion including laser (MBS item number: 41861)
•Microlaryngoscopy and laryngeal injection (MBS item number: 41870)
•Microlaryngoscopy and treatment of subglottic stenosis
- Willingness of the participant’s treating anaesthetist to enrolthe participant, in the absence of any identified contraindications.

Exclusion Criteria

- Baseline oxygen saturation level less than 95%
- Know history of lung disease, including but not limited to COPD and Type I or Type II respiratory failure.
- Body Mass Index (BMI) greater than 31.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Apnoea time between 30% oxygen concentration and apnoeic conditions following pre-oxygenation with 100% oxygen with THRIVE (ie. Time from reducing oxygen delivery concentration to laser-safe” level until rescue jet ventilation is required).<br><br>Time will be assessed using clock on anaesthetic machine (start and stop times) and also using stopwatch / timer on mobile phone to measure in seconds.<br> <br>[ Timepoint 1: Baseline (15 minutes prior to surgery)<br>Timepoint 2: Administration of THRIVE with 100% oxygenation (10 minutes prior to surgery)<br>Timepoint 3: Administration of either 30% oxygenation using THRIVE or room air oxygenation (approximately 30-45 seconds prior to laser surgery)<br>Timepoint 4: Oxygen saturation starts to drop (during laser surgery).<br>Timepoint 5: Oxygen saturation reaches a critical level requiring rescue (during laser surgery).<br>Timepoint 6: Jet rescue ventilation starts (during surgery).<br><br><br>]