Ethnic differences in body composition and substrate utilization: the effect of physical activity and diet.

Recruiting

• Conditions: substraatmetabolisme en insulineresistentie; oxidation of fat; protein and carbohydrate; substrate metabolism

• Registration Number: NL-OMON34820
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

The study includes healthy subjects with a BMI 20-27 kg/m2, aged 20-40 years, stable body weight in the last three months, not following a diet, not using medications except oral contraceptive and no family history of diabetes.

Exclusion Criteria

Subjects with chronic diseases known to affect energy metabolism (energy intake and/or expenditure) and athletes will be excluded.
Subjects that meet any of the exclusion criteria for MRI (electronic implants, pacemakers, metal fragments in the eyes, skin or body) will be excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters for the cross-sectional part are the differences in<br /><br>body composition, fat distribution, energy expenditure and substrate<br /><br>utilisation (including dietary fat oxidation). The main study parameters of<br /><br>the overfeeding-high fat diet intervention are the differences in abdominal fat<br /><br>content, liver fat and intramyocellular lipid content (IMCL) and glucose<br /><br>tolerance. The main study parameters for the sedentary life-style intervention<br /><br>are the differences and changes in gene expression related to in adipogenesis,<br /><br>lipogenesis and lipolysis as well as glucose tolerance. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Differences in physical activity between Asians and Caucasians<br /><br>• Differences in physical fitness between Asians and Caucasians<br /><br>• Differences in adipocyte size between Asians and Caucasians<br /><br>• Differences in blood lipid profiles at baseline and after overfeeding a high<br /><br>fat diet or a sedentary life-style between Asians and Caucasians </p><br>