The role of dopamine and noradrenaline in probability and reward value processing.
- Conditions
- dopamine antagonism, noradrenaline antagonism, subjective probability processing, subjective value processing, dopamine antagonisme, noradrenaline antagonisme, subjectieve waardevolheid, subjectieve waarschijnlijkheid.
- Registration Number
- NL-OMON27311
- Lead Sponsor
- trecht University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 36
Inclusion Criteria
Male, non-smoking, age between 18-45 years and passing the screening (assessing medical history and blood pressure/heart rate)
Exclusion Criteria
Psychopathology, current medication use, (history of) serious medical condition(s), low blood pressure, heart rate above 100 bpm or below 60 bpm in rest.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cue specific P200 event-related potential relative to no cue, cue specific P300 event-related potential relative to no cue. Independent variables: Subjective value, Subjective probability, dopaminergic antagonism by haloperidol and noradrenergic antagonism by clonidine.<br>
- Secondary Outcome Measures
Name Time Method - Velocity scaling measurement<br /><br>- Spontaneous motor activity measurement<br /><br>- Event related potentials in response to the target<br /><br>- Reaction times in response to the target<br /><br>- Target omissions and percentage correct responses<br /><br>- Questionnaire scores (attentional control, State-trait anxiety inventory)<br>