NL-OMON51949招募中不适用
Dopaminergic and noradrenergic dynamics after acute stress - DANDY
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 132
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •Age between 18 and 40
- •Right handed
- •BMI between 18.5 and 30
- •Normal or corrected to normal vision
- •Speaking and understanding of the English language
排除标准
- •Incompatibility with the MRI scanner
- •History of brain surgery
- •Possible pregnancy
- •Breastfeeding
- •Color blindness
- •Any relevant current or past psychiatric or psychotic disorder, including
- •suicidality
- •First degree family member with schizophrenia, bipolar disorder, or major
- •depressive disorder
- •Neurological disorder
- •Endocrine disorder
- •Endocrine treatment
- •Glaucoma or increased risk for glaucoma
- •Melanoma or undiagnosed skin lesion
- •Any other clinically significant hepatic, metabolic, obstructive respiratory,
- •renal, cerebrovascular, cardiovascular, oncological, ocular or pulmonary
- •disease/disorders
- •Raynaud*s syndrome
- •Hypersensitivity to Haloperidol or Propranolol
- •Hypertension (i.e. diastolic blood pressure >95 mmHg at rest, or systolic blood
- •pressure >180
- •mmHg at rest)
- •Hypotension (i.e. diastolic blood pressure <50 mmHg at rest, or systolic blood
- •pressure <95
- •mmHg at rest, or heart rate <45 bpm)
- •A-V block (PR interval longer than 0.20sec or irregular PR intervals)
- •Abnormal QTc-interval (higher than 450 for males, and 460 for females)
- •Frequent autonomic failure (fainting, dizziness, blurry vision)
- •Used prescribed medication within the last month
- •Use of *over the counter* medication within the last two months (excluding
- •paracetamol)
- •Dependence on alcohol or drugs
- •Use of alcohol within 24 hours before the test sessions
- •Average alcohol consumption of 3 beverages or more daily
- •Use of drugs within 72 hours before the test sessions
- •Cannabis use within 2 weeks prior to start of the study, weekly use for a
- •duration of at least 3
- •months in the last 6 months
- •Weekly or more use of recreational drugs or psychotropic medication
- •Habitual smoking (more than one pack in a week) or inability to cease smoking
- •for 24 hours
- •before testing
- •Irregular sleep/wake rhythm
- •Intense daily physical exercise
- •Native English speaker
研究者
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