Quality of Life in Patients With Primary Sclerosing Cholangitis

Not Applicable

Completed

• Conditions: Primary Sclerosing Cholangitis
• Interventions: Other: quality of life survey

• Registration Number: NCT02712736
• Lead Sponsor: Duke University

Brief Summary

The purpose of this study is to assess the healthcare-related quality of life (HRQOL), the impact of risk of liver transplant and risk of malignancy on HRQOL, and the complementary and alternative medicine use in patients with PSC.

Detailed Description

A cohort of adult (age ≥ 18) patients with a diagnosis of PSC will be identified. The patients will be approached about participating in the study while at their appointment, either by the investigators or someone else known to the patient. If the patient agrees, the investigators or other key personnel will then provide information about the study and obtain their informed consent to participate.

The patients who consent to participate will be sent home from the clinic with a survey to complete and return via mail in a provided addressed, stamped envelope. The survey consists of the Short Form-36 (SF-36), the Chronic Liver Disease Questionnaire (CLDQ), questions from the PROMIS SexFs v2.0, questions regarding perceived risk for liver transplant, cholangiocarcinoma, and colorectal carcinoma, as well as perceived overall life expectancy, and questions regarding complementary and alternative medicine use.

Demographic information and clinical data will also be obtained from the patient's electronic medical record. The study will be cross-sectional in nature, and there will be no follow-up with the subjects after the survey is completed.

Study Timeline

• Study First Submitted: 2016-03-11
• Study First Submitted QC: 2016-03-15
• Study First Posted: 2016-03-18
• Study Start: 2016-07-01
• Primary Completion: 2018-09-22
• Study Completion: 2018-09-22
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-28
• Last Update Posted: 2020-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• Adult (age ≥ 18) patients with PSC, confirmed by laboratory tests, imaging, and/or liver biopsy

Exclusion Criteria

• Patients <18
• Patients who have undergone liver transplant, patients with frank hepatic encephalopathy
• Patients with active inflammatory bowel disease (IBD) flares
• Patients with malignancies
• Patients unable to understand English
• Patients refusing to participate or provide informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Survey respondents	quality of life survey	The patients who consent to participate will be sent home from the clinic with a survey to complete and return via mail in a provided addressed, stamped envelope. The survey consists of the Short Form-36 (SF-36), the Chronic Liver Disease Questionnaire (CLDQ), questions from the PROMIS SexFs v2.0, questions regarding perceived risk for liver transplant, cholangiocarcinoma, and colorectal carcinoma, as well as perceived overall life expectancy, and questions regarding complementary and alternative medicine use.

Primary Outcome Measures

Name	Time	Method
Impaired quality of life as measured by questionnaire	Approximately 2 weeks

Trial Locations

Locations (1)

Duke University; 🇺🇸 Durham, North Carolina, United States