Leucine Supplementation Strategies to Enhance Muscle Anabolic Responses in Older Age
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Muscle protein synthesis in response to leucine feeding
研究概览
简要总结
Sarcopenia describes the progressive decline of muscle mass and strength with advancing age and is associated with increased frailty and morbidity, however we do not currently have an effective treatment. Protein feeding and exercise is known to increase muscle mass, but aged muscle shows a lower response to these stimuli leading to muscle loss over time. We do know that ingesting leucine, a building block of protein, can overcome this reduced response to protein feeding and exercise leading to increased muscle mass in older people. However, we do not understand when the optimum time to ingest leucine is to maximise muscle mass after exercise in older people. In this study we will examine the effect of feeding leucine after exercise either with a meal or between meals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 65 Years 至 75 Years（Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Male, 65-75 years of age
- •BMI 18-28 kg/m2
- •Non smoker
- •Not performing regular resistance type exercise
- •Participant is willing and able to give informed consent for participation in the study
排除标准
- •A BMI <18 or >28 kg·m-2
- •Active cardiovascular disease: uncontrolled hypertension (BP > 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt or recent cardiac event
- •Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial)
- •Respiratory disease including pulmonary hypertension or chronic obstructive pulmonary disease (COPD)
- •Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, types 1 or 2 diabetes (treated and untreated), inborn/ congenital errors of metabolism (e.g. phenylketonuria (PKU), galactosaemia)
- •Active inflammatory bowel disease
- •Acute infection
- •Acute or chronic renal disease
- •Malignancy (or history of malignancy with 5 y)
- •Recent steroid treatment (within 6 mo), or hormone replacement therapy
- •Coagulopathy
- •Musculoskeletal or neurological disorders
- •Known allergies to any of the product ingredients
- •Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
研究组 & 干预措施
Leucine supplementation between meals
Volunteers will take leucine supplements between breakfast and lunch, between lunch and dinner, and between dinner and supper.
干预措施: Leucine (Dietary Supplement)
Leucine supplementation with meals
Volunteers will take leucine supplements with breakfast, with lunch and with dinner.
干预措施: Leucine (Dietary Supplement)
结局指标
主要结局
Muscle protein synthesis in response to leucine feeding
时间窗: 7 days
To quantify muscle protein synthesis in response to feeding leucine with a meal or in-between meals using mass spectrometry.
次要结局
- Measure muscle anabolic and catabolic signalling pathways in response to leucine feeding(7 days)