NCT01192009
Completed
Not Applicable
Leucine and Skeletal Muscle Disuse: Clinical Anti-Atrophic Effectiveness and Related Mechanisms
ConditionsDisuse Atrophy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Disuse Atrophy
- Sponsor
- University of Sao Paulo
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Skeletal muscle structure (cross-sectional area)
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
Leucine supplementation is widely known for promoting strong influence on skeletal muscle remodeling. This study aims to evaluate the effect of leucine supplementation on disuse-induced skeletal muscle atrophy.
Investigators
Humberto Nicastro
PhD
University of Sao Paulo
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of anterior cruciate ligament injury
- •Physically active
- •Must be able to swallow tablets
- •Non-smokers
- •Do not use nutritional supplements
Exclusion Criteria
- •Post-surgical complications
Outcomes
Primary Outcomes
Skeletal muscle structure (cross-sectional area)
Time Frame: 2 weeks
Secondary Outcomes
- Molecular signalling pathways (hypertrophy, atrophy, and inflammation)(2 weeks)
Study Sites (1)
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