Leucine Supplementation and Skeletal Muscle Disuse

Not Applicable

Completed

• Conditions: Disuse Atrophy
• Interventions: Dietary Supplement: Leucine; Dietary Supplement: Placebo

• Registration Number: NCT01192009
• Lead Sponsor: University of Sao Paulo

Brief Summary

Leucine supplementation is widely known for promoting strong influence on skeletal muscle remodeling. This study aims to evaluate the effect of leucine supplementation on disuse-induced skeletal muscle atrophy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-08-30
• Study First Submitted QC: 2010-08-30
• Study First Posted: 2010-08-31
• Study Start: 2011-04
• Status Verified: 2013-02
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Last Update Submitted: 2013-02-22
• Last Update Posted: 2013-02-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 22

Inclusion Criteria

• Clinical diagnosis of anterior cruciate ligament injury
• Physically active
• Must be able to swallow tablets
• Non-smokers
• Do not use nutritional supplements

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Exclusion Criteria

• Post-surgical complications

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Immobilization and Leucine	Leucine	-
Immobilization and Placebo	Placebo	-

Primary Outcome Measures

Name	Time	Method
Skeletal muscle structure (cross-sectional area)	2 weeks

Secondary Outcome Measures

Name	Time	Method
Molecular signalling pathways (hypertrophy, atrophy, and inflammation)	2 weeks

Trial Locations

Locations (1)

University of São Paulo - School of Physical Education and Sports; 🇧🇷 São Paulo, Brazil