NCT03319147已完成不适用
Effect of Leucine-enriched Essential Amino Acid on Integrated Muscle Protein Synthesis and Muscle Recovery After Resistance Exercise
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Muscle protein synthesis
研究概览
简要总结
The primary objective is to determine the impact of essential amino acids on integrated muscle protein synthesis over 4 days after resistance exercise.
In addition, the secondary objective is to determine the effect of essential amino acids on satellite cell regulation and inflammatory responses during this prolonged recovery period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy, male, recreationally-active participants
- •Healthy will be defined as screened by the PAR-Q+ (The Physical Activity Readiness Questionnaire for everyone; Appendix. B). Active will be defined as being in the top 20% of age specific scores on iPAQ (the International Physical Activity Questionnaire; Appendix.C).
- •Participants are required not to engage in lower limb RT (resistance training) for at least 6 months prior to the study.
- •Participants will be 18-35 years old.
- •Participants are willing to abide by the compliance rules of this study
排除标准
- •Inability to adhere to any of the compliance rules judged by principle investigator or medical doctor
- •Self-reported regular tobacco use
- •Self-reported illicit drug use (e.g. growth hormone, testosterone, etc.)
- •The individual who has allergy for milk
结局指标
主要结局
Muscle protein synthesis
时间窗: 4 hours
Skeletal muscle fractional synthesis rate (%/h) will be determined by oral pulse method using ring-\[D5\]phenylalanine
次要结局
- exercise performance(4 days)
- Muscle soreness(4 days)
- Muscle damage(4 days)
研究者
Daniel Moore
Assistant Professor
University of Toronto
研究点 (2)
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