Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Signaling Pathways

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Leucine supplementation; Dietary Supplement: BCAA supplementation; Dietary Supplement: Alanine supplementation

• Registration Number: NCT01350427
• Lead Sponsor: University of Sao Paulo

Brief Summary

This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-05-02
• Study First Submitted QC: 2011-05-06
• Study First Posted: 2011-05-09
• Study Start: 2011-08
• Status Verified: 2013-02
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Last Update Submitted: 2013-02-22
• Last Update Posted: 2013-02-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 18

Inclusion Criteria

• Sedentaries
• Must be able to exercise
• Must be able to swallow tablets

Exclusion Criteria

• Use of nutritional supplements
• Use of anti-inflammatory drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Leucine	Leucine supplementation	-
BCAA	BCAA supplementation	-
Placebo	Alanine supplementation	-

Primary Outcome Measures

Name	Time	Method
Protein synthesis	1 hour	Phosphorylation of proteins involved in protein synthesis
Protein degradation	1 hour	Expression of protein involved in proteolytic pathway
Inflammation	1 hour	Expression of systemic and muscular cytokines

Trial Locations

Locations (1)

University of São Paulo - School of Physical Education and Sports; 🇧🇷 São Paulo, Brazil