Multicenter Study of Impulse Oscillometry in Chinese

• Conditions: Upper Airway Obstruction; Healthy Subjects; Asthma; Chronic Obstructive Pulmonary Disease; Interstitial Lung Disease
• Interventions: Other: Clinical Observation

• Registration Number: NCT03467880
• Lead Sponsor: Guangzhou Institute of Respiratory Disease

Brief Summary

The purpose of this study is to establish the reference values of impulse oscillometry (IOS) in healthy Chinese, and compare the indices of IOS in patients with lung disease, such as chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease (ILD), and upper airway Obstruction (UAO).

Detailed Description

Not available

Study Timeline

• Study Start: 2016-09
• Study First Submitted: 2018-02-14
• Status Verified: 2018-03
• Study First Submitted QC: 2018-03-10
• Last Update Submitted: 2018-03-10
• Study First Posted: 2018-03-16
• Last Update Posted: 2018-03-16
• Primary Completion: 2018-06
• Study Completion: 2018-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 4000

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Interstitial lung disease	Clinical Observation	Patience with interstitial lung disease.
Upper airway obstruction	Clinical Observation	Patience with upper airway obstruction.
Chronic obstructive pulmonary disease	Clinical Observation	Patience with chronic obstructive pulmonary disease.
Healthy subjects	Clinical Observation	Healthy subjects.
Asthma	Clinical Observation	Patience with asthma.

Primary Outcome Measures

Name	Time	Method
Airway resistance	one minute	The indices of Airway resistance include total respiratory impedance (Zrs).

Secondary Outcome Measures

Name	Time	Method
forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, and maximum midexpiratory flow (MMEF).	one minute	The indices of spirometry include forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, and maximum midexpiratory flow (MMEF).

Trial Locations

Locations (2)

State Key Laboratory of Respiratory Disease,China Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University; 🇨🇳 Guangzhou, China

Beijing Hospital; 🇨🇳 Beijing, China