Airway oscillometry after lung transplantatio

Not Applicable

Recruiting

• Conditions: Chronic Lung Allograft Dysfunction; Lung Transplantation; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12620001351909
• Lead Sponsor: St Vincent's Hospital Darlinghurst

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-12-14
• Last Update Posted: 5 January 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

We will recruit all post-operative lung transplant recipients who present to the hospital for routine surveillance over a 24 months period. Patients will be identified as appropriate for the study by the primary investigators. Written informed consent will be obtained by the primary investigators and study coordinators at each site.

Exclusion Criteria

Subjects will be excluded if they have a significant language barrier, pain or physical disability at the time of testing.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measurement of airway oscillometry indices R5, R5-19, X5, Ax at specified time intervals after lung transplantation. <br>[Cross-Sectional Cohort: 1 time point > 3 months after lung transplantation<br>Longitudinal Cohort: 3 time points at 3 months, 6 months and 12 months after lung transplantation]

Secondary Outcome Measures

Name	Time	Method
Assessment of the trajectory of airway closure will be determined by closure at %-total lung capacity (TLC). To determine closure at %-TLC, we will compare compare two derecruitment markers on the Xrs versus volume curve, the onset reduction of Xrs (DR1vol) and the onset of more rapid reduction of Xrs (DR2vol). [Cross-Sectional Cohort: 1 time point > 3 months after lung transplantation<br>Longitudinal Cohort: 3 time points at 3 months, 6 months and 12 months after lung transplantation];Assessment of the lung elastic recoil properties will be determined by X5. [Cross-Sectional Cohort: 1 time point > 3 months after lung transplantation<br>Longitudinal Cohort: 3 time points at 3 months, 6 months and 12 months after lung transplantation]