Impulse oscillometry for the diagnosis of bronchiolitis obliterans syndrome

Not Applicable

Active, not recruiting

• Conditions: Chronic lung allograft dysfunction; Chronic graft-versus-host disease of the lung (bronchiolitis obliterans); Respiratory - Other respiratory disorders / diseases; Blood - Other blood disorders; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12618001032246
• Lead Sponsor: Dr Thomas Crowhurst

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-06-20
• Last Update Posted: 16 January 2023

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 121

Inclusion Criteria

Bilateral Lung transplant recipient
- 18 years old or more

OR:

- Allogeneic haematopoietic stem cell transplant recipient
- 18 years old or more

Exclusion Criteria

In lung transplant recipients, allograft dysfunction from causes other than BOS or RAS, including:
- BOS / RAS overlap
- Active non-BOS alloinflammatory processes (e.g. acute cellular rejection, lymphocytic bronchiolitis and antibody-mediated rejection)
- Active allograft infection
- Mechanical impediment:
- Known upper / large airway obstructive pathology (e.g. anastomotic stricture or stricture to level of segmental bronchus)
- Pleural complications such as pneumothorax, infection or pleural effusion
- Neuromuscular deficits (e.g. diaphragmatic paralysis)
- Uncontrolled cardiac failure of any cause
- Recurrent of primary disease in allograft

In allogeneic haematopoietic stem cell transplant recipients, lung dysfunction from causes other than bronchiolitis obliterans including:

- Active pulmonary infection
- Mechanical impediment:
- Known upper / large airway obstructive pathology
- Pleural complications such as pneumothorax, infection or pleural effusion
- Neuromuscular deficits (e.g. diaphragmatic paralysis)
- Uncontrolled cardiac failure of any cause
- Pre-existing lung disease that is more than mild in severity (either obstructive or restrictive)

Study & Design

• Study Type: Observational
• Study Design: Not specified